The "Office Handshake" meme features two characters from the American TV show "The Office," specifically Michael Scott (Steve Carell) shaking hands with a more formally dressed individual. The image originates from promotional material for the show, showcasing Michael Scott's unique, often awkward, and unprofessional demeanor in contrast to a standard business setting. The meme is typically used to represent an uncomfortable, mismatched, or absurd interaction or comparison between two differing entities or ideas. It highlights a clash of styles, expectations, or levels of formality, often humorously depicting one side as clearly out of place or unprepared while attempting a formal exchange.